HomeFarm AnimalsOJD in Sheep: Causes, Signs, Diagnosis and Treatment

OJD in Sheep: Causes, Signs, Diagnosis and Treatment

Ovine Johne’s Disease (OJD), also known as paratuberculosis or Johne’s disease, primarily affects ruminants, including sheep. Ovine Johne’s disease is caused by the bacterium Mycobacterium avium subspecies paratuberculosis (MAP). The disease primarily targets the small intestine, leading to chronic inflammation and eventual thickening of the intestinal walls. Infected animals may experience weight loss, diarrhea, and reduced milk production.

Causes of OJD in Sheep

Ovine Johne’s Disease (OJD) in sheep is caused by the bacterium Mycobacterium avium subspecies paratuberculosis (MAP). Here are key points regarding the causes and transmission of OJD:

  • Mycobacterium avium subspecies paratuberculosis (MAP):
    • MAP is the causative agent of OJD in sheep. It is a slow-growing, acid-fast bacterium that primarily affects the small intestine of ruminants.
  • Infection Source:
    • Sheep typically contract OJD through the ingestion of MAP-contaminated material. This can include contaminated feed, water, soil, or surfaces contaminated with infected feces. Additionally, transmission can occur through the consumption of milk or colostrum from infected ewes.
  • Environmental Persistence:
    • MAP is known for its ability to survive in the environment for extended periods. This environmental persistence contributes to its transmission between sheep in a flock or from one flock to another.
  • Vertical Transmission:
    • Lambs can become infected with MAP before or during birth through exposure to contaminated materials. Vertical transmission from infected ewes to their offspring is a possible route of infection.
  • Asymptomatic Carriers:
    • Some sheep may become carriers of MAP without displaying clinical signs of OJD. These carriers can shed the bacteria in their feces, contributing to environmental contamination and potential disease spread.
  • Stress and Crowding:
    • Stress and overcrowding can exacerbate the spread of OJD. These conditions may weaken the immune response of the sheep, making them more susceptible to infection.

Bannur Sheep of India

Clinical Signs of Ovine Johne’s Disease

Ovine Johne’s Disease (OJD) is a chronic and often progressive infection in sheep caused by the bacterium Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs of OJD may not be apparent in the early stages, and infected animals can remain asymptomatic for an extended period. However, as the disease progresses, various clinical signs may become noticeable. Remember that not all infected sheep will exhibit the same symptoms, and the severity of clinical signs can vary. Common clinical signs of OJD include:

  • Weight Loss:
    • One of the hallmark signs of OJD is progressive weight loss. Infected sheep may experience a gradual decline in body condition despite maintaining a seemingly normal appetite.
  • Chronic Diarrhea:
    • Sheep with OJD may develop chronic diarrhea, which is often watery and may persist over an extended period. Diarrhea in sheep can contribute to further weight loss and dehydration.
  • Reduced Wool Production:
    • Infected sheep may exhibit a decline in wool production. The wool may become coarse, and the quality can deteriorate as the disease progresses.
  • Emaciation:
    • In the advanced stages of OJD, affected animals may become emaciated due to the combination of weight loss, reduced appetite, and persistent diarrhea.
  • Weakness and Debilitation:
    • As the disease advances, affected sheep may become weak and debilitated. Their ability to graze, move, and interact with the flock may be significantly compromised.
  • Swelling of the Jaw and Throat Area (Bottle Jaw):
    • In some cases, sheep with OJD may develop swelling in the jaw and throat region, known as “bottle jaw.” This can occur due to protein loss and fluid accumulation in the tissues.

Diagnosis of OJD in Sheep

The diagnosis of Ovine Johne’s Disease (OJD) in sheep involves a combination of clinical observations, laboratory tests, and post-mortem examinations. Here are the critical aspects of diagnosing OJD in sheep:

  • Clinical Observations:
    • Veterinarians and farmers observe the flock for clinical signs of OJD. These signs may include weight loss, chronic diarrhea, reduced wool production, and overall poor body condition. However, clinical signs alone may not be sufficient for a definitive diagnosis, as they can vary, and some infected animals may not exhibit noticeable symptoms.
  • Serological Testing:
    • Blood tests, such as enzyme-linked immunosorbent assay (ELISA) or polymerase chain reaction (PCR), can be employed to detect the presence of antibodies or DNA specific to Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of OJD. These tests can help identify infected animals, even without clinical signs.
  • Fecal Culture:
    • Fecal culture involves isolating and growing MAP from fecal samples. This method is more time-consuming and may take several weeks to obtain results, but it is a definitive way to confirm the presence of the bacterium.
  • Post-Mortem Examination:
    • Necropsy (post-mortem examination) is a crucial diagnostic tool for OJD. Examination of the intestines, particularly the ileum and associated lymph nodes, may reveal characteristic lesions and thickening of the intestinal walls. Tissue samples can be collected for histopathological examination to confirm the presence of MAP.
  • Combining Diagnostic Methods:
    • A combination of diagnostic methods is often used for a more accurate diagnosis. For example, serological testing may be complemented by fecal culture or post-mortem examination to enhance diagnostic reliability.
  • Monitoring and Surveillance:
    • Regular monitoring and surveillance of flocks, especially those at risk, can aid in early detection. This involves testing healthy animals to identify subclinical infections and implementing control measures to prevent further spread.

Treatment of OJD in Sheep

There is no specific and effective treatment for Ovine Johne’s Disease (OJD) in sheep. OJD is a chronic and progressive disease caused by Mycobacterium avium subspecies paratuberculosis (MAP), and once an animal is infected, the bacterium can be challenging to eliminate.

Prevention of Ovine Johne’s Disease

Preventing and managing Ovine Johne’s Disease (OJD) in sheep involves a combination of biosecurity measures, monitoring, and, in some regions, vaccination. Here are key strategies for preventing OJD:

  • Closed Flock Management: Maintain a closed flock to prevent the introduction of infected animals. Avoid bringing sheep from outside sources, as this can introduce Mycobacterium avium subspecies paratuberculosis (MAP) into the flock.
  • Quarantine and Testing: Implement a thorough quarantine process for any new animals entering the flock. Test incoming animals for OJD, and only introduce animals that test negative. This helps prevent the introduction of infected individuals into the flock.
  • Biosecurity Measures: Implement strict biosecurity practices to reduce the risk of MAP transmission within the flock. This includes:
    • Avoiding contact with other potentially infected animals.
    • Maintaining clean and sanitary conditions in barns, pastures, and equipment.
    • Preventing the sharing of equipment and tools between flocks.
    • Minimizing the risk of contamination from manure and other waste materials.
  • Vaccination: In some regions, vaccination against OJD is used as a preventive measure. The vaccine aims to reduce the severity of clinical signs and shedding of MAP. Consult with veterinary authorities to determine the suitability and availability of vaccines in your region.
  • Monitoring and Surveillance: Regularly monitor the flock for clinical signs of OJD. Additionally, conduct testing for MAP, especially in healthy animals, to identify subclinical infections and implement control measures promptly.
  • Culling Infected Animals: If OJD is confirmed in the flock, consider culling infected animals to prevent further spread. Culling is often an essential component of disease control strategies.
  • Educational Programs: Educate farmers, herders, and other stakeholders about OJD, its transmission, and prevention measures. Awareness and understanding play a crucial role in implementing effective biosecurity practices.
  • Research and ConsultationStay informed about the latest research on OJD prevention and control. Consult with veterinary experts and authorities to ensure your management practices align with current best practices.

Concluding Remarks on OJD in Sheep

In conclusion, Ovine Johne’s Disease (OJD) poses a significant challenge for sheep farmers worldwide. This chronic and often fatal disease, caused by Mycobacterium avium subspecies paratuberculosis (MAP), affects the small intestine of sheep and can lead to weight loss, chronic diarrhea, and decreased productivity. While there is no cure for OJD, implementing effective prevention and control measures is crucial for minimizing its impact on sheep flocks.

Latest Post

Editors' Pick

Editors' Pick